Tammy, living with asthma and allergies in the US
People living with type 2 inflammatory diseases often feel limited by unpredictable symptoms and isolated in their experiences. Living with these chronic diseases—often more than one—and searching for control, they have looked for answers and found few.
Recent scientific developments have shown that excessive type 2 inflammation, an overactive immune system response, underlies different atopic, allergic and inflammatory diseases.1-3 The lack of awareness of type 2 inflammation means people may not fully understand their disease(s), how they are connected, and the treatment options available to them.
See the faces and hear the stories of people living with these diseases around the world:
1 N. A. Gandhi, B. L. Bennett and N. M. Graham, “Targeting key proximal drivers of type 2 inflammation in disease,” Nature Reviews Drug Discovery,vol. 15, no. 1, pp. 35-50, 16 October 2016.
2 S. Carr, E. Chan, and W. Watson, “Eosinophilic esophagitis,” Allergy, Asthma & Clinical Immunology, vol. 14, no. Suppl 1, p. 58, 2018.
3 J. W. Steinke and J. M. Wilson, “Aspirin-exacerbated respiratory disease: pathophysiological insights and clinical advances.,” Journal of Asthma and Allergy, vol. 9, pp. 37-43, 2016.
4 https://www.aaaai.org/conditions-and-treatments/conditions-dictionary/Eosinophilic-Esophagitis. Accessed September 2019.
5 https://www.aaaai.org/conditions-and-treatments/related-conditions/eosinophilic-esophagitis. Accessed September 2019.
6 https://www.aaaai.org/conditions-and-treatments/conditions-dictionary/atopic-dermatitis-(eczema). Accessed September 2019.
7 Mount Sinai. Patient Care Atopic Dermatitis 2016. http://www.mountsinai.org/patient-care/health-library/diseases-andconditions/atopic-dermatitis#risk. Accessed Sept. 9th, 2019.
8 https://www.aaaai.org/conditions-and-treatments/conditions-dictionary/Asthma. Accessed September 2019.
9 Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. 2018. Available at: http://ginasthma.org/download/832/. Accessed July 2018.
10 Gandhi NA, Pirozzi G., Graham NMH. Commonality of the IL-4/IL-13 pathway in atopic diseases. Expert Review of Clinical Immunology. 2017;13:5:425-437.
11 https://www.aaaai.org/conditions-and-treatments/conditions-dictionary/Nasal-Polyps. Accessed September 2019.
12 Newton JR, Ah-See KW. A review of nasal polyposis. Ther Clin Risk Manag. 2008;4(2):507-12.
13 Newton JR, Ah-See KW. A review of nasal polyposis. Ther Clin Risk Manag. 2008;4(2):507-12.
14 https://my.clevelandclinic.org/health/diseases/16759-asa-triad. Accessed September 2019.
15 https://www.aaaai.org/conditions-and-treatments/conditions-dictionary/food-allergies. Accessed September 2019.