Guy Bongongo, 12, suffers from sleeping sickness, with his father in the Democratic Republic of Congo
Photo credit: Kimpavita Films-DNDi
After 20 years in development, the new oral drug fexinidazole for the treatment of Human African Trypanosomiasis, or sleeping sickness, has found its way to one of the first patients to receive the medicine, Guy Bongongo, a 12-year-old boy from the Democratic Republic of Congo (DRC), the country most at risk from the disease.
Contracted from a parasite transmitted through the bite of a tsetse fly, sleeping sickness can prove fatal if not diagnosed and treated in time.
Developed by Sanofi in partnership with the non-profit organization, Drugs for Neglected Diseases initiative, the treatment for this neglected tropical disease (NTD) will play a key role in achieving the World Health Organization’s (WHO) global target of eliminating the disease by 2020. Sanofi donates fexinidazole to the WHO for distribution.
The latest figures show an encouraging downward trend in sleeping sickness infections. In 2018, 977 cases of sleeping sickness were reported, down from 2,164 reported cases in 2016.1
As the WHO sets out its 2021-2030 roadmap for NTDs in a virtual webinar on June 17, Luc Kuykens, Senior Vice President of Sanofi Global Health Programs, will participate in a discussion on “Partnerships, Collaboration & Integration for Impact: The Key to 2030 success?”, and will share Sanofi’s journey of international collaboration, medical research and the logistical hurdles to deliver fexinidazole to remote populations in the DRC.
Fexinidazole is the first treatment indicated for both first-stage (haemo-lymphatic) and second-stage (meningo-encephalitic) disease and its oral tablet format has revolutionized how the disease is managed. Previously, patients could only receive treatment by travelling to specialized centers, often far from home, putting patients at risk of losing their jobs and livelihoods as well as placing a heavy financial burden on a country’s healthcare systems. Today, trained healthcare workers can administer the 10-day course of drugs to patients in their local communities.