Immunology and Inflammation R&D

We’re an emerging leader in immunology, poised to transform medicine by rebalancing the immune responses that cause systemic, chronic diseases.
Illustration of substances being released at a cell’s surface leading to inflammation.
Illustration of substances being released at a cell’s surface leading to inflammation.
When it comes to immunology, we’re thinking bigger and digging deeper than a single drug.
Dietmar Berger

Dietmar Berger

Global Head of Development

Illustration of inflammation at a cell’s surface
Illustration of inflammation at a cell’s surface

Our immunology pipeline

Our teams use real-world, molecular, and clinical data to advance precision medicine, and investigate:

  • pathways common to systemic diseases like asthma and atopic dermatitis
  • peripheral inflammatory diseases like rheumatoid arthritis
  • autoimmune challenges in type 1 diabetes and cancer

Follow the Science

Taking Down Type 2 Inflammatory Disease

We’re working to tame over-active immune responses that drive systemic, chronic diseases.

From Wearables to Invisibles: Studying Sleep

Using AI and wireless tech, we’re helping people participate in research from home.

REGAINing Control of Asthma

We’re leveraging smart devices to understand the patient experience.

Type 2 inflammation

Our goal: to give people their lives back by calming excessive inflammation–without compromising their ability to fight infection.

With our partner Regeneron, we study how blocking two interleukins1 can help calm type 2 inflammation, a driver of atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, and other conditions.

Beyond type 2 inflammation

Precision Immunology

Single-cell genomics, genetics, and proteomics help us understand exactly what makes patients different from one another.

Checkpoint Immunology

How can we restore the delicate balance between a protective immune response and destructive autoimmunity?2
 

Complement System

Can we stop a cascade of inflammation without compromising immunity, by blocking one protein?3
 

More about Immunology

Your Health: Immunology

On Track to Lead in Immunoscience

Careers in R&D: Virginia Savova

References

  1. Mifflin L, Ofengeim D, Yuan J (2020) Nat Rev Drug Discov 19:553-571; DOI: 10.1038/s41573-020-0071-y
  2. Calabrese LH, et al. (2020) J Autoimmun 115:102546; DOI: 10.1016/j.jaut.2020.102546
  3. Nikitin PA, et al. (2019) J Immunol 202:1200-1209; DOI: 10.4049/jimmunol.1800998

Page updated August 2023

MAT-GLB-2004283 v-2.0 6/2023