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Research & Development

As researchers, we are passionate about scientific excellence because what we do today may improve the lives of people tomorrow. We work to transform scientific knowledge and medical advances into cutting-edge therapies to improve people’s lives worldwide. Discovering solutions for the world’s most pressing medical needs is our top priority.

Our R&D community is made up of scientists, physicians, technicians, product and manufacturing engineers and world-class innovators, all of whom contribute to our scientific leadership. Our goal is breakthrough innovation that can transform, extend and potentially save lives. 

As people live longer, chronic conditions are on the rise. New viruses and diseases are emerging, while old enemies like cancer and neurodegenerative diseases remain. Sanofi is driven by the scope of these health challenges.

Innovative approaches

To unlock tomorrow’s science to develop the latest treatments, Sanofi’s R&D community is: 

  • investing in multi-targeting therapies to tackle multiple diseases with a single drug;
  • working on combination therapies to make treatments more effective;
  • developing new biologics to produce precision medicines;
  • conducting breakthrough research to unlock the potential of gene therapy;
  • leveraging artificial intelligence and innovative digital technologies to empower patients to better manage chronic conditions.

 

R&D Portfolio

At the end of October 2020, the R&D pipeline contained 84 projects, including 34 new molecular entities in clinical development (or that have been submitted to the regulatory authorities). Thirty-four projects are in phase 3 or have been submitted to the regulatory authorities for approval.

Research areas

Sanofi is investing in these research areas to find innovative solutions for patients:

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Oncology
Despite incredible progress by scientists and drug developers over the last 20 years, cancer remains the second leading cause of death worldwide. Sanofi is combining its extensive heritage in small molecule research with new biologic capabilities to move cancer therapy forward. To achieve this, the company is leveraging multiple technology platforms, including monoclonal antibodies, messenger RNA (mRNA), and antibody drug conjugates - antibodies that are used as a unique delivery system to deliver drugs to where they are needed to combat cancer in the body.

 

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Immunology & Inflammation

In recent years, Sanofi has led the science in immunology by introducing new treatment options for chronic, difficult-to-treat inflammatory diseases such as atopic dermatitis (eczema), asthma and rheumatoid arthritis. Sanofi is applying the most advanced research technologies and is focused on inflammatory conditions and autoimmune diseases with the highest unmet need. One of its key approaches is to develop multi-specific antibody therapies that combine multiple mechanisms of action in a single molecule and that target two or more molecular pathways simultaneously.

 

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Rare Blood Disorders
With Ablynx and Bioverativ joining the Sanofi family, the company is now spearheading an industry-leading franchise to treat rare blood disorders. Sanofi continues to build on its legacy of innovation, from the development of the first extended half-life clotting factors for treating hemophilia A and B, using a range of technologies including further engineering clotting factor fusion proteins, small interfering RNA and gene therapy. It is developing novel therapies using insights into the complement mediated pathophysiology of other rare blood disorders, such as cold agglutinin disease, a chronic autoimmune hemolytic condition for which there are no approved therapies. Sanofi is also working to address the significant unmet medical need in sickle cell disease and other hemoglobinopathies with both small molecule and ex vivo gene editing approaches.

 

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Rare and Neurologic Diseases

Sanofi is committed to developing transformative therapies for patients with rare and neurologic diseases. Its expertise has led to pioneering medicines for rare lysosomal storage disorders such as Fabry, Gaucher and Pompe diseases, as well as disease modifying therapies for Multiple Sclerosis. The company’s research has advanced novel approaches to treat rare kidney diseases and neurodegenerative diseases such as Parkinson's disease associated with glucocerebrosidase (GBA) gene mutations to clinical trials. A cornerstone of its efforts includes developing gene therapies for inherited neurologic, ophthalmologic, metabolic and lysosomal storage disorders.

 

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Vaccines

Sanofi Pasteur is at the forefront of vaccine research and development, creating immunological solutions to prevent and cure diseases for every stage of life. It continuously harnesses new scientific knowledge and technologies to design safe and effective vaccines against complex diseases. Innovation is key to improving people's health around the world and also to the company's success. That is why it devotes more than €1 million to research and development every day. Sanofi Pasteur works every day to turn scientific breakthroughs and personal health insights into protective vaccines for people around the world.

Next Generation Approaches to Pioneer Tomorrow's Breakthrough Therapies

Next Generation Approaches to Pioneer Breakthrough Therapies

At Sanofi, we are developing medicines that have the potential to help transform patients’ lives by using the most advanced technology platforms to pioneer new innovative approaches to tackle diseases.

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