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Parents at home holding their baby, who has experienced a severe RSV infection.

Yaya and Xuanxuan, parents, China. Advocates for awareness of respiratory syncytial virus (RSV) infection in infants.

Yaya and Xuanxuan, parents, China. Advocates for awareness of respiratory syncytial virus (RSV) infection in infants.

Understanding RSV (Respiratory Syncytial Virus) in Infants

Symptoms, Risks & Prevention

Respiratory Syncytial Virus (RSV) is a common and highly contagious virus that can lead to serious respiratory illness in some infants1. While it often causes mild cold-like symptoms, RSV is the most common cause of lower respiratory tract disease (LRTD), including bronchiolitis and pneumonia, in infants, and is a leading cause of infant hospitalization2, 3. Understanding RSV symptoms, risks, and prevention options can help parents and caregivers protect infants during their first years of life.

What Is RSV and What Are the Risks for Infants?

RSV is a common, contagious seasonal virus that will infect nearly all children by their second birthday1. The RSV season typically runs from fall through spring in the northern hemisphere4. In temperate climates, RSV seasonality is aligned with the cold season, from late fall to early spring. In tropical and subtropical climates, RSV seasonality is less consistent with the peak usually aligned with rainy season and/or higher temperatures4, 5.

In many cases, RSV causes mild cold-like symptoms, such as a runny nose, cough, or fever6. However, RSV is also the most common cause of lower respiratory tract infections in infants, including bronchiolitis and pneumonia 7. 

RSV is a leading cause of hospitalization in all infants, including healthy babies born at full term2, 3. Most RSV-related hospitalizations occur in infants who were born healthy and without underlying medical conditions8. Older infants born before the RSV season are also at risk, accounting for around half of infant RSV hospitalizations9, 10.

Beyond hospitalizations, RSV is responsible for a significant outpatient burden in children aged 2 and younger11, 12. Around 1 in 5 children will require outpatient medical care because of RSV by the age of two13. Although deaths from RSV are uncommon in high-income countries, severe disease can still occur, even in otherwise healthy infants2, 7.
Because RSV can affect any baby, regardless of their month of birth or overall health, understanding the virus, recognizing symptoms early, and learning about prevention options and measures are important steps in helping protect infants.

~1 in 5

children will require outpatient medical care because of RSV by the age of 213

50%

of hospitalizations occur in babies born before the season9,22,28,29,30,31,32

+70%

of infant hospitalizations due to RSV are among healthy and full-term infants2,9,28

What Are the Symptoms of RSV Infection?

RSV symptoms often begin like those of a common cold, including a runny or blocked nose, cough, and sometimes a fever6. In most cases, these symptoms are mild and resolve on their own.

However, RSV can sometimes spread to the lower respiratory tract and cause more serious illnesses, such as bronchiolitis or pneumonia6. As the infection progresses, breathing difficulties may develop.

Signs of a more severe respiratory infection can include6:

  • Fast, short, or shallow breathing
  • Wheezing (a high-pitched whistling sound when breathing)
  • Flaring of the nostrils while breathing
  • Difficulty feeding or drinking due to breathing problems
  • Unusual tiredness, sleepiness, or low energy
  • Persistent fever
  • A bluish color around the lips or fingernails, which may indicate low oxygen levels

Other signs and symptoms may occur, and not all signs and symptoms may be observed or experienced. The above signs and symptoms can occur in respiratory infections caused by other viruses or bacteria.

RSV infections can worsen quickly in some infants. It's important to seek advice from a healthcare professional promptly whenever you have concerns about a child's health.

How Does RSV Spread?

RSV is a highly contagious virus that spreads through respiratory droplets when an infected person coughs, sneezes, or talks. It can also spread through direct contact or by touching contaminated surfaces and then touching the nose, mouth, or eyes. RSV can survive on surfaces for several hours, making it easy to transmit in households and childcare settings6, 14, 15. RSV is up to 4 times more contagious than influenza16, 17.

Most people infected with RSV experience only mild, cold-like symptoms and may not realize they're carrying the virus, yet they can still spread it to others. RSV is most commonly spread to babies by:

  • Older siblings who have been infected at school or daycare14
  • Other children in daycare centers or play areas14
  • Adults who may be momentary carriers without displaying symptoms18

Each person infected with RSV can spread the virus to an average of 4.5 people16, allowing it to circulate widely in the community.

Babies are particularly vulnerable to RSV because their immune system and lungs are still developing, and their airways are small and fragile in early life. This increases their susceptibility to respiratory infections and the risk of lower respiratory tract conditions19-21, such as bronchiolitis compared with older age groups.

While most RSV infections are mild, all infants remain at risk of developing more serious respiratory infections, like bronchiolitis or pneumonia7.

Is RSV Illness Predictable?

Parents at home holding their baby, who had experienced a severe RSV infection.
Yaya and Xuanxuan with their infant. Advocates for awareness of respiratory syncytial virus (RSV) infection in infants.

RSV disease can be difficult to predict, and it is not possible to know which infants will develop severe illness requiring medical care8, 22.

While most RSV infections are mild and children recover at home, some infants may develop serious respiratory symptoms that affect their breathing and require medical attention. Severe RSV infections can occur even in healthy infants with no underlying medical conditions6. Approximately 1 in 50 infants will be hospitalized during their first year of life23.

Because it is difficult to predict which infants will develop severe RSV infections, awareness of the virus and its potential complications, and understanding of the prevention options, can help parents and caregivers protect infants. 

Who Is Most at Risk of a Severe RSV Infection?

Parent gently holding their infant's hand while the baby lies in a crib, in the context of respiratory syncytial virus (RSV).
Yaya and Xuanxuan with their infant, China.

All infants are at risk, whether born healthy or with underlying health conditions, term or pre-term, during or before RSV season22, 24, 25. This is because their lungs and immune systems are developing throughout their first year and beyond21, 26, 27.

In fact, more than 70% of infant hospitalizations due to RSV are among healthy and full-term infants2,9,28 and 50% of hospitalizations occur in babies born before the season9,22,28,29,30,31,32.

Because a severe RSV infection can occur in any infant, whether born full-term or preterm, healthy or with underlying health conditions, it is not possible to predict which babies will develop serious illness requiring medical care.

How Is an RSV Infection Treated in Infants?

There is generally no specific treatment for RSV itself. Instead, management focuses on relieving symptoms to help infants stay comfortable while their immune system fights the infection. In most cases, RSV infections can be managed at home with symptomatic care, though some infants may require medical attention or hospitalization depending on the severity of their symptoms. In the case of concern about a child's health, it's important to seek medical advice in a timely manner.

How Can RSV Be Prevented in Infants?

RSV is a highly contagious virus1. While there is no specific treatment for RSV, there are preventative options available to help protect infants against RSV disease. A healthcare professional (such as a doctor, nurse or pharmacist) can provide more information about this.

Additionally, here are some preventive measures and barrier measures to help reduce the chance of an RSV infection33

Wash hands frequently

Clean hands thoroughly with soap and water for at least 20 seconds, especially before handling the infant or after contact with sick people

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Frequently Asked Questions About RSV

What is Respiratory Syncytial Virus (RSV)?

RSV is a common respiratory virus that infects the nose, throat, and lungs. It typically causes mild, cold-like symptoms6, but can lead to serious illness in infants, young children, and older adults34. RSV is highly contagious1 and spreads through respiratory droplets and contact with contaminated surfaces.

References

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