The Uncertainty of Living with Atopic Dermatitis

Imagine going to bed each night not knowing whether you’ll be physically able to go to school or work, look after your family, go to the gym or do the shopping. For people living with uncontrolled moderate-to-severe atopic dermatitis (AD), this uncertainty can be a daily reality.

AD is a chronic inflammatory disease with an unpredictable nature. Its symptoms, including itching, dry skin, flaking, cracking, bleeding, and oozing, may suddenly worsen, and can cause substantial disruption to the lives of people with the disease and their loved ones.1

To mark World Atopic Dermatitis Day 2020, Sanofi Genzyme and Regeneron are launching the second "Agents of Change" AD Challenge, which is focused on addressing the uncertainty of daily life with AD.

"Agents of Change" 2020 AD Challenge-World AD Day Video

While people living with AD and those close to them may be aware of the unpredictable nature of their disease, friends, co-workers, classmates and others they interact with may not understand the realities of living with a disease that can flare-up without warning and at times have an impact that goes beyond what is visible.2,3

The continuous uncertainty around when the next flare may occur can lead to fear and anxiety for some, which can in turn hold them back from living life to the fullest.4,5

About the "Agents of Change" AD Challenge 2020

This year’s challenge is seeking creative ideas that address one, or both, of the following interlinked goals: To help people living with AD navigate the daily unpredictability of their disease, and to help friends, coworkers, classmates and others understand, empathize with and better support people with AD through the uncertainty they face each day.

The "Agents of Change" AD Challenge is a global grants initiative seeking proposals for grassroots solutions to help solve some of the greatest common challenges impacting those living with AD. 

The "Agents of Change" initiative aims to tackle issues head on by working to harness the motivation and creativity of people with AD, their families and those around them to deliver transformative solutions for some of the biggest burdens of life with this chronic disease. 

By harnessing the power of collaborative innovation and opening the challenge to ideas both big and small from around the world, Sanofi’s aim is to help support the development of initiatives that make a meaningful difference.

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1 Mount Sinai. Patient Care Atopic Dermatitis. Available at: Accessed May 2020.
2 Weidinger S and Novak N. Atopic dermatitis. Lancet. 2016;387:1109–1122.
3 Bieber T. Atopic Dermatitis. Ann Dermatol. 2010;22(2):125–137.
4Zuberbier T, Orlow S and Paller A. Patient perspectives on the management of atopic dermatitis, J Allergy Clin Immunol, 2006;118(1):226-232.
5 Torrelo A. Atopic dermatitis: impact on quality of life and patients' attitudes toward its management. Eur J Dermatol 2012;22:97–105.